CONCLUSION Bacterial endotoxin test can be used in place of the rabbit pyrogen test for monitoring bacterial endotoxin of procaine hydrochloride for injection. 结果注射用盐酸普鲁卡因对鲎试剂的凝聚反应无干扰作用。
CONCLUSION These results suggest that the technique of TAL-test could be used to replace the rabbit pyrogen test for Heparin sodium injection. 结论所用方法检查肝素钠注射液中细菌内毒素可行,可用细菌内毒素检查法代替家兔热原检查法。
Objective To study the relationship between the determination results of bacterial endotoxin by limulus test and rabbit test, and to determine the limit of bacterial endotoxin content in the product according to the threshold value defined in pyrogen test in rabbits. 目的研究鲎试剂法与家兔法检测重组人干扰素α2b内毒素结果的相关性,并参照家兔热原试验的阈值量,来确定本制品质量标准中内毒素的限量标准。
Objective To study the influence of rabbit tolerance induced by endotoxin on pyrogen test, providing the basis for appropriate selection of rabbit in pyrogen test, and establishing a decrease of temperature more than 0.6 ℃ as a criterion for result evaluation. 目的研究内毒素耐受性家兔对热原检查的影响,为热原检查中正确选择家兔、在结果判断中直接将家兔体温下降超过0.6℃作为判定指标提供依据。
The cardiovascular pharmacological actions of two new ceramides ( N1 and N2) were studied. Isolated guinea-pig hearts test, Isolated rabbit aortic strips test and hypotensive test on anesthetized rats were used. 采用豚鼠离体心脏、兔胸主动脉条和麻醉大鼠急性降压等实验,初步观察了两种新的神经酰胺(代号分别为N1和N2)对心血管的药理作用。
Methods The rabbit skin stimulus test, mucous membrane of rectum stimulus test, and guinea pig skin hypersensitivity test were used. 方法采用家兔皮肤刺激性试验、家兔直肠黏膜刺激性试验和豚鼠皮肤过敏性试验。
Conclusions The results suggest that Bacterial Endotoxins test ( gel-clot method) can be used as an alternative method for the rabbit pyrogen test for Chlorpromazine Hydrochloride Injection. 结论该制剂可以用细菌内毒素检查法(凝胶法)代替兔热原检查法控制其产品质量。
Rabbit eye sensitivity test to chitosan 壳聚糖家兔眼刺激试验
Conclusion The bacterial endotoxins could be used for this specimen instead of pyrogen test, and the result was the same as rabbit test. 结论本品可用细菌内毒素检查法代替热原检查法,且结果一致。
The results of rabbit skin irritation test and Guinea pig skin allergia test make it certain that ATPs is safe for topical administration. 家兔皮肤刺激性试验结果表明,ATPs对完好皮肤无刺激性,对破损皮肤具有轻度刺激;豚鼠过敏性试验结果显示ATPs无致敏性。
By means of IFT 、 rabbit cross immunity test and ELISA we diagnosed the clinical case of Hog Cholera Virus ( HCV). The MZ strain of HCV was isolated. 试验中采用直接荧光抗体检测、兔体交互免疫试验和ELISA检测方法确诊猪瘟临床病例,分离了猪瘟野毒MZ株。
Result: The test had no disturbed by sample solution of 1: 2 which was the same as rabbit test. 结果:1:2样品溶液无干扰作用,与家兔法结果一致。
Conclusion Turbidimetric-kinetic method is feasible, it can be used as an alternative method for the rabbit pyrogen test to Danhong injection. 结论使用细菌内毒素动态浊度法定量检测丹红注射液中的污染内毒素是可行的,可用细菌内毒素定量检测代替家兔热原检查法。
A Novel Test for the Detection of Pyrogen in order to Replace the Rabbit Pyrogen Test by Determination of the Release of TNF-α from Human Whole Blood 一种替代家兔热原试验的新方法初探&检测人全血中的TNF-α
Results: Toxicity tests, in vitro with CHO cells and in vivo by the rabbit ideal loop test, demonstrated that the mutant K 63 has remarkable detoxicity. 结果:CHO细胞体外试验和家兔肠结扎体内试验毒性测定的结果表明,LT突变体K63的毒性明显降低。
Result: The test was not interference by the diluted solution ( 1:6) Conclusion: The bacterial endotoxin test method could be used for this specimen instead of pyrogen test, and the result was the same as rabbit test. 结果:克林霉素磷酸酯氯化钠注射液经1:6稀释后,对细菌内毒素检查法无干扰。结论:克林霉素磷酸酯氯化钠注射液可用细菌内毒素检查法代替热原检查法,且结果一致。
The anti-endotoxin effect of Radix Isatidis was determined with limulus test and rabbit pyrogenic test before and after three doses of γ ray radiation. 本文用3个剂量的γ射线辐照板蓝根药材,并用鲎试剂法与家兔法测定辐照前后板蓝根抗内毒素作用的变化。
Conclusion: The method is proved to be suitable for determination of the BET in Co-Salvia miltiorrhiza Injection and could be used as an alternative method for the rabbit pyrogen test to the injection. 结论:使用动态浊度法定量检测复方丹参注射液的细菌内毒素是可行的,可用细菌内毒素方法代替兔热原检查法,同时又避免了限量法内毒素检测时的干扰。
Between Rabbit Pyrogen Test and Limulus Amebocyte Lysate Test Comparative Studies for Detecting Endotoxin in IFN and Serum Albumin 鲎试验和家兔法测定干扰素和白蛋白中内毒素的比较
Objective: To study the ability of gel clot method instead of rabbit pyrogen test for the bacterial endotoxin determination of tinidazole and glucose injection. 目的:确定凝胶法代替家兔热原检查法检测替硝唑葡萄糖注射液细菌内毒素的可能性。
The live-weight gain of rabbit test by control feeding method 限制饲养法对家兔增重的影响试验初报
The diphtheria antitoxin titre of guinea pigs immunized with DTP Vaccine were detected by vero cell method and compared with those by rabbit skin neutralization test. Vero细胞法测定DTP疫苗中白喉类毒素的效价与家兔皮内中和法(简称NT法)所得结果两法之间有一种平行关系,并且有很好的相关性,r=0.93。
Skin irritation testing and rabbit vaginal irritation test were used to evaluate safety associated with TF gel application. 通过皮肤过敏性实验以及家兔阴道粘膜刺激性实验,对家兔阴道使用2%TF凝胶剂进行初步安全性评价。
The current quality control standard of Matrine and Glucose Injection is the one standard approved by State Food and Drug Administration. According to the standard, the pyrogen is determined in rabbit pyrogen test. 苦参碱葡萄糖注射液现行质量标准为国家食品药品监督管理局批准的试行标准,根据该试行标准规定,该产品的热原检查用家兔法。
Succeeded in using mice replacement of rabbit to test bivalence vaccine efficacy, and this method can reduce reduce test cost, and more sensitive, specific, objective and simple. 以实验动物小白鼠代替本动物进行二价疫苗效力检验取得成功,本效力检验方法可降低检验成本,具有更敏感、更特异、更客观、更简便等特点。
By adopting irritant experimental methods of intraperitoneal injection towards mice and the rabbit eye irritant test, we compare the irritant effect of the samples of crude and processed Homalomena gigantea Engl. and produce pathological sections of rabbit cornea tissue. 采用小鼠腹腔刺激性实验方法、家兔眼刺激性实验方法,比较炮制前后的大黑附子各样品的刺激性作用,并做家兔眼角膜组织病理切片。